pentobarbital will lower the level or result of trazodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will reduce the extent or influence of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will lower the extent or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will minimize the level or influence of vardenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will lessen the level or outcome of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Double brexpiprazole dose over one-two weeks if administered with a robust CYP3A4 inducer.
Remark: Barbiturates may boost adverse effects, such as respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates enhance metabolism and reduce blood concentrations of TCAs.
With therapeutic doses of TCAs, barbiturates maximize metabolism and reduce blood concentrations of TCAs.
pentobarbital will lower the level or effect of tolterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Check Intently (two)pentobarbital will lower the level or result of buprenorphine, very long-performing injection by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. People who transfer to buprenorphine extensive-performing injection from transmucosal buprenorphine coadministered with CYP3A4 inducers ought to be monitored to make sure buprenorphine plasma degrees are ample.
pentobarbital will reduce the level or influence of etoposide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Keep track of Intently (1)pentobarbital will reduce the extent or influence of hydrocodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Warning when discontinuing CYP3A4 inducers which can be coadministered with hydrocodone; plasma concentrations of hydrocodone could improve and can result in likely fatal respiratory depressionSerious - Use Alternate (one)hydrocodone, pentobarbital.
buprenorphine subdermal implant and pentobarbital both equally increase sedation. Stay clear of or Use Alternate Drug. Restrict use to sufferers for whom choice procedure solutions are inadequate
pentobarbital will decrease the extent or influence of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Steer clear of coadministration of lefamulin with solid or reasonable CYP3A inducers Except if the reward outweighs dangers. Keep track of for reduced efficacy.
pentobarbital get more info will lessen the level or effect of nitrendipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.